Frequently Asked Questions

OmegaXL is a premium, natural, drug-free joint health supplement derived from sustainably sourced New Zealand green-lipped mussels. Backed by more than 40 years of clinical research, OmegaXL helps reduce joint pain and muscle soreness caused by overuse or aging and supports a healthy inflammatory response.

OmegaXL’s active ingredient, PCSO-524®, contains over 90+ fatty acids, including EPA and DHA, and naturally occurring Specialized Pro-Resolving Mediators (SPMs), compounds your body produces to support the resolution phase of inflammation.

SPMs act as natural signals that support your body's resolution phase of the inflammatory process, clearing cellular debris and restoring joints and muscles to a balanced, functional state. The result is less joint pain, muscle soreness, and stiffness, and better mobility. *

With consistent daily use, most people begin to feel a difference within 4 weeks, with the best results typically experienced at 8 weeks. *

Most omega-3 supplements come from fish. OmegaXL is different. OmegaXL is made from the oil extract of green-lipped mussels, sustainably farmed in the pristine waters of New Zealand's Marlborough Sound, not harvested from unknown ocean areas and sources.

Each mussel is grown for 18 months and filters 25 gallons of antioxidant-rich plankton daily, producing a unique blend of fatty acids and Specialized Pro-Resolving Mediators (SPMs) not found in any other source or supplement. Our proprietary CO2 extraction process yields a natural oil extract free of harmful levels of toxins, heavy metals, and polychlorinated biphenyls (PCBs).

OmegaXL contains more than 90 free fatty acids, including EPA, DHA, and ETA. Notably, ETA is a unique fatty acid found in green-lipped mussel oil but not in conventional fish oil. It also contains naturally occurring specialized pro-resolving mediators (SPMs)—compounds that support the body’s inflammation resolution process and are not typically found in standard omega-3 supplements.

OmegaXL is specifically formulated for joint and muscle health and is not a general cardiovascular omega supplement. It is natural, drug-free, and non-habit forming; you can take it every day for decades.

SPMs, or Specialized Pro-Resolving Mediators, are compounds your body naturally produces from omega-3 fatty acids to help resolve the inflammatory phase of inflammation.

Inflammation is a natural process, but your body needs to resolve it to bring the process to a healthy close. Specialized pro-resolving mediators (SPMs) play a critical role in this “finish signal.” They help your immune system clear cellular debris and restore affected tissue to its normal, balanced state. Without sufficient SPM activity, inflammation may persist longer than it should, leading to joint pain and muscle soreness.

As you age, your body’s natural ability to produce SPMs declines, which may contribute to more persistent joint discomfort and slower recovery.

OmegaXL is derived from green-lipped mussel oil, which is naturally rich in SPMs and helps replenish what your body produces less of as you age. This is not found in standard fish oil products. It is one of the things that makes OmegaXL genuinely different.

OmegaXL is designed for adults who want to stay mobile, active, and independent and do not want their joint and muscle discomfort to slow them down.

• Support joint mobility, flexibility, and strength
• Reduce occasional joint stiffness, aches, and soreness
• Support muscle recovery and comfort after physical activity
• Promote a healthy inflammatory response

Whether you're on your feet all day at work, staying active in retirement, getting back to things you love, or simply moving through life more comfortably, OmegaXL is built for daily, long-term joint and muscle support.

OmegaXL is for adults who want to stay mobile, active, and independent and who want to do it naturally, without a prescription.

• Notice that your joints and muscles do not recover the way they once did.
• Have a physically demanding job. Whether it’s construction, food service, lifting, or standing all day at a retail counter, or you rely on your body every day to do its job.
• Are staying active in retirement and want to keep it that way: pickleball, dancing, playing with the grandkids, traveling.
• Are getting back to things you love after joint pain and muscle soreness put you on the sideline.
• Want to take a high-quality, natural, drug-free daily supplement that supports your joints and muscles long-term.

OmegaXL is intended for adults 18 and older. It is not appropriate for children under 18. OmegaXL is designed to support joint and muscle health, not as a general cardiovascular omega-3 supplement. If you are pregnant, nursing, or taking prescription medications, please consult a healthcare professional before use.

OmegaXL is natural, made with ingredients you can recognize. There are no prescriptions needed and no habit-forming ingredients.

We suggest 4 gel capsules daily, preferably with a meal, for the first 8 weeks. All 4 may be taken at once, or two in the morning and two at night -- whatever works best for you. You may begin to feel improvement after 2 weeks but expect the best results after 8 weeks of daily use.

Consistency is key. OmegaXL works by gradually increasing fatty acid levels in your body over time, which means daily use is what creates results, not timing.

• Most people find it easiest to integrate OmegaXL into an existing routine, whether at breakfast, at dinner, or alongside whatever supplements they already take daily.
• OmegaXL can be taken with or without food. Choose a time, stick with it, and let consistency do the work.

OmegaXL is not designed to give you instant results. It is designed to work with your body to naturally support joint health. Taking OmegaXL daily as recommended allows the over 90+ beneficial fatty acids and naturally occurring specialized pro-resolving mediators (SPMs) to build up in your body over time. These special compounds work with your body’s natural ability to resolve inflammation at the cellular level. This is why it’s important to take OmegaXL consistently every day.

Make OmegaXL part of your daily routine. Take OmegaXL consistently as directed, even on days when you feel your best. Let the nutrients build up and continue supporting your joints day after day. While everyone’s experience is different, most people begin to notice a difference around 4 weeks, with optimal results typically achieved after 8 weeks of consistent use.

Think of OmegaXL as part of your daily wellness routine, similar to other habits that support long-term health. With consistent use over time, the benefits continue to build and become more noticeable.

Yes, and that is exactly how OmegaXL is designed to be used.

OmegaXL is natural, drug-free, and non-habit-forming. OmegaXL works with your body's natural processes. There is no known risk associated with consistent, long-term daily use when taken as suggested.

In fact, long-term daily use allows you to take advantage of OmegaXL’s full range of benefits. The fatty acids and SPMs accumulate over time, and people who take it consistently, day after day, are the ones who feel less pain and experience better mobility.

OmegaXL is formulated with three key clean ingredients, with no fillers or unnecessary additives—providing full transparency into what you are putting into your body.

• PCSO-524® Proprietary Green-Lipped Mussel Oil Extract: This oil extract is sustainably sourced from the pristine waters of New Zealand's Marlborough Sound. PCSO-524® delivers over 90 fatty acids, including EPA, DHA, and ETA, in free-fatty-acid form, as well as naturally occurring SPMs.
• Extra Virgin Olive Oil and Pure Olive Oil: These carrier oils work together to help your body better absorb and utilize the beneficial fatty acids found in OmegaXL. Olive oil is a “functional” oil with its own health and wellness properties and protects the bioactivity of the sensitive lipid compounds.
• Vitamin E (d-alpha Tocopherol): This is a natural antioxidant that protects the integrity of the oil blend.

The softgel capsule is made from gelatin. OmegaXL is small, easy to swallow, and can be taken daily as part of your health routine. OmegaXL is non-GMO, gluten-free, dairy-free, and free of harmful levels of toxins, heavy metals, and PCBs.

OmegaXL is manufactured in the USA using globally sourced ingredients at a facility that operates in full compliance with cGMP standards as regulated by the FDA. Every production lot is tested to meet or exceed our strict quality requirements before shipment.

The active ingredient in OmegaXL, PCSO-524® green-lipped mussel oil extract, comes from New Zealand's Marlborough Sound, one of the world's most pristine and unpolluted marine environments. The mussels are sustainably farmed there, not harvested from unknown open-ocean sources. They are grown on man-made vines underwater, in water you can trust.

The additional ingredients are sourced from carefully selected global suppliers.

OmegaXL is a natural, drug-free supplement designed with your quality and safety in mind. When taken as directed, it has no known side effects and does not require a prescription.

Every bottle of OmegaXL is manufactured in the United States from globally sourced ingredients in facilities that fully comply with Current Good Manufacturing Practices (cGMPs) as regulated by the FDA. Each production lot is rigorously tested to ensure the product meets or exceeds quality standards before distribution.

• Harmful levels of toxins, heavy metals, and PCBs
• Gluten and dairy
• Allergenic levels of shellfish protein
• Genetically modified organisms (GMOs)

The FDA does not review dietary supplements before they are released to the market. However, the FDA regulates the supplement industry by enforcing cGMP requirements, conducting routine facility inspections, and monitoring products sold to the public. OmegaXL is manufactured in accordance with these standards.

As with any supplement, individuals who are pregnant, nursing, under 18, or taking prescription medications should consult a healthcare provider before taking the supplement.

OmegaXL is a natural, drug-free supplement with no known side effects when taken as suggested.

OmegaXL contains molluscan shellfish oil. Our proprietary extraction process removes the allergenic proteins. If you have an allergy, it is best to introduce any new supplement into your diet under the supervision of a healthcare provider.

Please consult your healthcare provider before use.

OmegaXL is commonly taken alongside other supplements, including Vitamin D3 and joint or wellness supplements, without issues when used as directed.

As with any supplement, individuals taking prescription medications or managing a medical condition should consult a healthcare professional before use to ensure it is appropriate for their needs.

OmegaXL is a dietary supplement, not a pharmaceutical drug, so it does not undergo FDA drug approval. This is true of all dietary supplements in the United States, and it is part of what makes OmegaXL accessible: no prescription required, no pharmacy visit, no waiting room.

OmegaXL is manufactured in accordance with strict quality and safety standards, from the mussel farm to your front door. It is produced in the United States using globally sourced ingredients at a facility that operates in full compliance with Current Good Manufacturing Practices (cGMPs). Each production lot is rigorously tested to ensure it meets or exceeds established quality standards before release. In addition, the facility undergoes random FDA inspections to maintain consistent oversight and compliance.

While the FDA does not pre-approve dietary supplements, it regulates their manufacturing through cGMP requirements, inspections, and quality standards. OmegaXL is produced in accordance with these regulatory requirements to ensure safety, purity, and potency.

With the exception of holidays, all orders received will be processed and shipped within 48 hours and delivered within 3-5 business days. Please be advised OmegaXL is shipped through the United States Postal Service, and at times there may be delays or disruptions in service due to weather or other US events. Please allow additional time for delivery.

OmegaXL is eligible for purchase using Health Savings Account (HSA) and Flexible Spending Account (FSA) funds through our partner Truemed.

To use your HSA or FSA card, select Truemed as your payment method at checkout on omegaxl.com. Truemed handles the eligibility process, and a Letter of Medical Necessity may be required depending on your plan. Truemed helps you obtain one if needed.

HSA and FSA payment applies to both one-time purchases and AutoShip orders. That means you can get OmegaXL delivered on auto-ship and pay for it with your HSA or FSA funds.

If you have questions about your plan's specific eligibility requirements, contact your HSA or FSA plan administrator. For questions about using Truemed at omegaxl.com, call Customer Care at 1-800-488-8082.

Different return and refund policies apply based on the product purchased:

Please note that each of these policies applies only to products purchased directly from Great HealthWorks by phone or at www.omegaxl.com .

You are currently receiving your order as part of our monthly auto-ship program. Through our monthly auto-ship program, you secured OmegaXL at a discounted price, and will enjoy this discount for as long as you continue your monthly auto-ship. If you would like to adjust your frequency of delivery, please contact our Customer Care department at 1.800.488.8082 .

We can pause one item or your entire account so that you do not accumulate any additional product while you take your current supply as directed on the product label. Call our Customer Care department at 1.800.488.8082 , and let the agent know you would like to pause your order, or use our convenient account modification form .

We can quickly update your address by contacting our Customer Care department at 1.800.488.8082 .